Tanayott Thaweethai, PhD, and Andrea S. Foulkes, ScD, led a manuscript titled, “Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection,” published online in the Journal of the American Medical Association (JAMA) on May 25, 2023. This high-impact work, which has already drawn the attention of several national news outlets, proposes a preliminary symptom-based rule that can be used to identify cases of postacute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID. Their paper leverages data collected and analyzed from 9764 participants in the RECOVER adult cohort, a prospective longitudinal cohort study. Several other MGH Biostatistics members were major contributors to this publication including co-authors Caitlin A. Selvaggi, MS, Daniel J. Shinnick, MS, and Carolin Schulte, PhD. This is a significant launching point for future research into understanding risk factors, mechanisms of disease, and potential therapies for long COVID.