David Schoenfeld, PhD

David Schoenfeld headshot

Senior Investigator, Biostatistics, Massachusetts General Hospital

Professor of Medicine, Emeritus, Harvard Medical School


David Schoenfeld developed the first omnibus goodness of fit test for the proportional hazards regression model, a model that is used extensively in clinical trials which have survival or time to progression as an endpoint.

He also developed widely used graphical techniques for this model. He authored a popular web site for sample size considerations for clinical trials. He has also developed, along with Dianne Finkelstein, a method of combining endpoints in clinical trials which is favored by the Food and Drug Administration, and he has done research in Bayesian methods for evaluating historically controlled trials and small pediatric trials.

Dr. Schoenfeld directs the Clinical Coordinating Center for the Prevention and Early Treatment of Acute Lung Injury Clinical Network, a national group doing clinical trials in Sepsis and Respiratory Failure.

He collaborates with diverse groups at Massachusetts General Hospital, including the Clinical Research Center, many of the units in the Endocrine division, the Transplant Program, the Coordinating Center for the Cancer Genetics Network, and the Burn Unit. He has an active research program and is a leading statistician in Clinical Trials in Amyotrophic Lateral Sclerosis(ALS).