David Schoenfeld, PhD

David Schoenfeld headshot

Senior Investigator, Biostatistics, Massachusetts General Hospital

Professor of Medicine, Emeritus, Harvard Medical School

David Schoenfeld developed the first omnibus goodness of fit test for the proportional hazards regression model, a model that is used extensively in clinical trials which have survival or time to progression as an endpoint. 

He also developed widely used graphical techniques for this model. He authored a popular web site for sample size considerations for clinical trials. He has also developed, along with Dianne Finkelstein, a method of combining endpoints in clinical trials which is favored by the Food and Drug Administration, and he has done research in Bayesian methods for evaluating historically controlled trials and small pediatric trials. 

Dr. Schoenfeld was the principal investigator of the Clinical Coordinating Center for the Prevention and Early Treatment of Acute Lung Injury Clinical Network and its successor the Prevention and Early Treatment of Acute Lung Injury network, a national group doing clinical trials in Sepsis and Respiratory Failure. He is a leading statistician in Clinical Trials in Amyotrophic Lateral Sclerosis(ALS). 

Currently he is available on a per diem basis for short term consultations on the design and analysis of clinical trials.